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. 2023 Apr 19;14:1138666. doi: 10.3389/fphar.2023.1138666

FIGURE 8.

FIGURE 8

Oral administration of DORA-22 induces sleep in a mouse model of schizophrenia. (A–O) Time course (A–F), total amount (G–I), mean duration (J–L), and episode number (M–O) of SWS, REMS, and wakefulness in MAP6 (STOP) knockout (KO) and wild-type (WT) mice after administering vehicle or DORA-22. (P) Wake episode spectrum in MAP6 (STOP) KO mice. (Q) Latency to sleep onset in MAP6 (STOP) KO and WT mice after administering vehicle or DORA-22. (R,S) EEG power density of SWS for 6 h after administering vehicle or DORA-22 into MAP6 (STOP) KO (Q) and WT (R) mice. Data (n = 6/group) are presented as mean ± SEM. Significance levels are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001.