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. 2023 Apr 19;14:1147772. doi: 10.3389/fphar.2023.1147772

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Copyright © 2023 Li, Li, Zhao, Wang, Xue, Chen, Li, Xu, Wang, Liu, Tian and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of GPX4, ACSL4, HDAC1 and HDAC2 in acute kidney injury from human biopsies. Representative images of immunohistochemistry of GPX4 and ACSL4 (A), HDAC1 and HDAC2 (B) in the healthy control and AKI human kidney biopsy specimens. Scale bar = 50 μm. Quantification of examining positive staining area of GPX4 and ACSL4 (C), HDAC1 and HDAC2 (D) in tubulointerstitium normalized to healthy control (Non-tumor kidney tissue from the patients who had renal cell carcinoma and underwent nephrectomy was used as control). n = 3. ✱✱ value p < 0.01. Statistically analyzed via a one-way ANOVA with Dunnett’s correction.