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. 2023 Apr 19;14:1147772. doi: 10.3389/fphar.2023.1147772

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Copyright © 2023 Li, Li, Zhao, Wang, Xue, Chen, Li, Xu, Wang, Liu, Tian and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VPA treatment attenuates expression of ferroptosis-related proteins in cisplatin-induced AKI mice. Representative images of immunofluorescence of GPX4 in the tubulointerstitium of sham, cisplatin and VPA or Fer-1 treatment groups. Quantification of examining positive staining area of GPX4 in the tubulointerstitium normalized to sham group (A). Immunohistochemical staining and semi-quantitative analysis for expression of ACSL4 (B) in different groups as indicated. Representative images of Western blot from different groups as indicated, including ACSL4 and GPX4, respectively (C). Scale bar = 50 μm. n = 5. ✱✱ value p < 0.01, ✱ value p < 0.05. Statistically analyzed via a one-way ANOVA.