(A) Superimposed view of RaptorX-predicted (in dark blue) and tFold-predicted (in green) human NOX1 model. (B) Superimposed view of RaptorX-predicted (in dark blue) and AlphaFold-predicted (in pink) human NOX1 model. (C) Superimposed view of RaptorX-predicted human NOX1 model (in dark blue) and previously reported csNOX5 model (PDB ID: 5O0T for transmembrane domain, PDB ID: 5O0X for dehydrogenase domain, shown in yellow). (D) Superimposed view of RaptorX-predicted human NOX1 model (in dark blue) and previously reported human DUOX1 model (PDB ID: 7D3E, chain A, shown in orange). Root mean square distance (RMSD) were calculated and shown for structural similarity. (E) Superimposed view of RaptorX-predicted human NOX1 model (in dark blue) and human NOX2 transmembrane region model (PDB ID: 7U8G, chain A, shown in salmon red).