Table 2. Hazard ratios, absolute risk differences, and numbers needed to harm to cause 1 outcome at 5 and 10 years.
| Outcome | Unadjusted analyses | Adjusted analyses* | Absolute risk difference (additional events per 10,000 patients per year) | Number needed to harm | ||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | aHR | 95% CI | Events | 95% CI | 5 years | 10 years | |
| Falls (primary outcome) | 2.19 | 2.15 to 2.23 | 1.23 | 1.21 to 1.26 | 6 | 6 to 7 | 431 | 158 |
| Hypotension | 2.43 | 2.39 to 2.48 | 1.32 | 1.29 to 1.35 | 7 | 6 to 7 | 434 | 153 |
| Syncope | 2.02 | 1.98 to 2.05 | 1.20 | 1.17 to 1.22 | 5 | 5 to 6 | 429 | 183 |
| Fracture** | 1.45 | 1.43 to 1.47 | 0.99 | 0.97 to 1.01 | 0 | −1 to 0 | - | - |
| Acute kidney injury | 2.92 | 2.88 to 2.96 | 1.44 | 1.41 to 1.47 | 16 | 15 to 17 | 174 | 64 |
| Electrolyte abnormalities | 2.64 | 2.60 to 2.68 | 1.45 | 1.43 to 1.48 | 14 | 14 to 15 | 205 | 72 |
| Gout | 1.99 | 1.97 to 2.02 | 1.35 | 1.32 to 1.37 | 13 | 12 to 14 | 135 | 79 |
*Models adjusted for propensity score.
**Absolute risk difference too small to estimate number needed to harm
aHR, adjusted hazard ratio; CI, confidence interval.