Table 1.
Lung Cancer Risk Prediction Models
| Models | |||||||
|---|---|---|---|---|---|---|---|
| Model Name | Bach [23] | TSCE* CPS* [20] | LLP [21] | Spitz [24, 25] | Knoke [22] | Hoggart [24] | PLCOm2012 [18] |
| Database | Carotene and Retinol Efficacy Trial (CARET) | Two ACS* Cohorts & British Doctors Cohort | Liverpool Lung Project (LLP)-case control | MD Anderson Database | ACS first cancer prevention study (CPS-1) | European Prospective Investigation into Cancer and nutrition (EPIC) | Prostate, Lung, Colorectal and Ovarian Screening Trial (PLCO) |
| Sample Size | 18,172 | Multiple Cohorts | 4,055 | 3,852 | 174,993 | 169,035 | 115,185 |
| Age of cohort in years | 50-69 +45-69*1 | Three different cohorts | 50-75 | 20-80 (no age restriction) |
40-80 | 40-65 | 55-74 |
| Risk Factors | |||||||
| Age | x | x | x | x | x | x | x |
| Gender | x | x | x | x | x | ||
| Smoking characteristics | x | x | x | x | x | x | x |
| Race | x | ||||||
| Education | x | ||||||
| BMI* | x | ||||||
| COPD/Emphysema | x | x | x | ||||
| H/O Cancer | x | X | |||||
| F/H of Cancer | x | x | X | ||||
| H/O Pneumonia | x | ||||||
| Asbestos Exposure | x | x | |||||
| Dust Exposure | x | ||||||
* TCSE = Two-Stage Clonal Expansion; CPS = Cancer prevention Study; ACS = American Cancer Society; BMI= Body mass Index
*1 = CARET had two cohorts of different ages.
X = Parameter was used in risk calculation score