Table I.

FDA Approved Products Developed Using Complexation Technique

Complexing agent	Dosage Form	Active Ingredient	Marketed product	Approval Date	Uses	Ref
Inclusion Complexation
Cyclodextrin	Oral chewable	Cetirizine HCl	CHILDREN'S ZYRTEC ALLERGY	2007	Taste Masking	[23]
	Oral	Drospirenone + Ethinyl estradiol	YAZ	2001	Stability of Ethinyl estradiol	[24]
	Topical gel	Metronidazole	METROGEL	1988	Solubility	[25]
HPβCD	Injection	Telavancin	VIBATIV	2009		[26]
		Diclofenac sodium	DYLOJECT	2014		[27]
		Letermovir	PREVYMIS	2017		[28]
		Tecovirimat	TPOXX	2018		[29]
	Oral solution	Larotrectinib	VITRAKVI	2018		[30]
	Oral solid	Cladribine	MAVENCLAD	2019		[31]
SBEβCD	Injection	Remdesivir	VEKLURY®	2020		[32]
		Voriconazole	VFEND®	2002		[33]
		Delafloxacin	BAXDELA	2017		[34]
		Posaconazole F	Noxafil	2006		[35]
		Brexanolone	ZULRESSO	2019		[36]
		Fosphenytoin sodium	CEREBYX®	1996	stability	[37]
Ion-resin Complexation
Sodium polystyrene sulfonate	Extended-release chewable tablet	Methylphenidate hydrochloride	QuilliChew ER.	2015	Prolong dissolution	[38]
	Extended-release oral suspension	Methylphenidate hydrochloride	QUILLIVANTTM XR	2012		[39]
	Extended-release oral suspension	Chlorpheniramine polistirex; codeine polistirex	TUZISTRA XR	2015		[40]
	Extended-release oral suspension	Chlorpheniramine polistirex; hydrocodone polistirex	TUSSIONEX PENNKINETIC	2012
	Extended-release oral suspension	Dextromethorphan polistirex	DELSYM	2017		[41]
Pharmacosomes
Phospholipid [1-α-dimyristoylphosphatidylcholine (DMPC) and l-α-dimyristoylphosphatidylglycerol (DMPG)]	Injection	Amphotericin B	ABELCET	1995	Biodistribution and reduce toxicity	[42, 43]
Metal Complexes
Silver	Topical cream	Silver sulfadiazine	Silvadene	1982	Pharamcodynamics propertics	[44]
Zinc	Ophthalmic ointment	Bacitracin zinc	Lumi-sporyn	1982	stability	[45]