Table III.
Recent Research on Complexation-based Pharmaceutical Dosage Forms
| Drug | Type of Complexation | Method of Preparation | Outcome | Reference |
|---|---|---|---|---|
| Galangin | Inclusion Complex (β-CD) | Nanoprecipitation | Improved solubility, dissolution, and pharmacokinetics | [55] |
| Carbamazepine | Inclusion Complex (β-CD and HPβ-CD) | Hot Liquid Extrusion | Improved solubility, dissolution, and pharmacokinetics | [56] |
| Naringenin | Ternary Inclusion Complex (HPβ-CD and hydrophilic polymers) | Hot Melt Extrusion | Improved solubility and dissolution | [57] |
| Sorafenib tosylate | Inclusion Complex (β-CD) | Kneading method | Improved solubility and dissolution | [58] |
| Atomoxetine hydrochloride | Inclusion Complex (β-CD) | Kneading method | Taste masking | [59] |
| Azithromycin | Ion-exchange resin complexaion (Kyron T-135 and Doshion-P542 AB) | Batch process | Taste masking | [60] |
| Quinine hydrochloride dihydrate | Ion-exchange resin complexaion (Amberlite™ IRP88 and Amberlite™ IRP64 | Hot Melt Extrusion | Taste masking | [61] |
| Ursolic acid | Pharmacosome (hydrogenated soybean phophatidylcholine) | Reflux method | Bioavailability and hepatoprotectivity | [62] |
| Heparin | Pharmacosome (Soy lecithin) | Solvent evaporation method | Bioavailability | [63] |
| Flurbiprofen | Organic molecular complexes (Lidocaine) | Solvent evaporation method | Enhancing solubility and permeability of Flurbiprofen | [64] |