. 2023 May 3;131(5):057001. doi: 10.1289/EHP11814

Table 4.

Associations of ln-transformed plasma PFAS concentrations with PCOS-related infertility in logistic regression model for women from Shanghai, Shandong, and Zhejiang provinces, China ( $lowercase italic n equals 943$ ), 2014–2016.

PFAS^a	Crude OR (95% CI)^b	$p$ -value	Adjusted OR (95% CI)^c	$p$ -Value
Legacy PFAS
PFOA	1.05 (0.86, 1.25)	0.86	1.07 (0.83, 1.36)	0.61
T-PFOS	1.16 (1.05, 1.32)	0.01	1.27 (1.08, 1.45)	0.007
PFNA	1.02 (0.85, 1.20)	0.85	1.13 (0.89, 1.44)	0.42
PFDA	1.02 (0.76, 1.28)	0.62	1.08 (0.85, 1.32)	0.27
T-PFHxS	1.20 (0.92, 1.54)	0.07	1.26 (0.98, 1.65)	0.22
PFHpS	1.01 (0.81, 1.23)	0.08	1.06 (0.85, 1.28)	0.16
PFDoA	1.21 (1.10, 1.36)	0.01	1.32 (1.17, 1.49)	0.005
PFUnDA	1.06 (0.86, 1.27)	0.36	1.15 (0.89, 1.46)	0.28
PFAS isomers
n-PFHxS	1.02 (0.92, 1.15)	0.16	1.08 (0.96, 1.22)	0.07
br-PFHxS	1.12 (1.02, 1.25)	0.03	1.18 (1.05, 1.34)	0.02
n-PFOS	1.12 (1.01, 1.32)	0.06	1.22 (1.07, 1.41)	0.01
$6 lowercase m-uppercase p f o s$	1.16 (0.91, 1.42)	0.16	1.25 (0.98, 1.53)	0.08
$1 lowercase m-uppercase p f o s$	1.17 (1.02, 1.34)	0.02	1.27 (1.09, 1.49)	0.009
$uppercase sigma 3,4,5 lowercase m-uppercase p f o s$	1.26 (1.08, 1.45)	0.04	1.35 (1.12, 1.57)	0.002
PFAS alternatives
6:2 Cl-PFESA	1.21 (1.08, 1.36)	0.0009	1.29 (1.11, 1.52)	0.0007
8:2 Cl-PFESA	1.14 (0.86, 1.42)	0.36	1.18 (0.91, 1.47)	0.26
HFPO-DA	1.26 (1.11, 1.47)	0.01	1.39 (1.16, 1.68)	0.006
Short-chain PFAS
PFBS	1.15 (0.81, 1.49)	0.42	1.26 (0.91, 1.60)	0.25
PFBA	0.78 (0.65, 0.96)	0.02	0.86 (0.69, 1.07)	0.07
PFPeS	1.17 (1.02, 1.31)	0.03	1.19 (1.04, 1.37)	0.04
PFPeA	1.05 (0.82, 1.28)	0.12	1.11 (0.91, 1.31)	0.85
PFHxA	1.20 (1.04, 1.35)	0.02	1.21 (1.06, 1.39)	0.01
PFHpA	1.19 (0.90, 1.47)	0.22	1.16 (0.74, 1.57)	0.52

Note: BMI, body mass index; CI, confidence interval; OR, odds ratio; PCOS, polycystic ovarian syndrome; PFAS, per- and polyfluoroalkyl substances.

^{^a}

For full chemical names see Table 1.

^{^b}

Logistic regression models were carried out to assess the OR and 95% CI of PCOS, which were estimated by 1-standard deviation higher difference in ln-transformed PFAS as continuous variables.

^{^c}

Adjusting for age (linear), BMI (categorical), annual household income (categorical), educational level (categorical), study site (categorical), age at menarche (linear), and menstrual volume (categorical).