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Mechanisms underlying CAND1 dissociation from CUL1-RBX1
(A) Cryo-EM maps showing conformations of CAND1Δβ-hairpin-CUL1-RBX1.
(B) Comparing CAND1 engaged and rolling-2 conformations shows shifts in contacts between CAND1’s anti-neddylation domain, RBX1’s RING domain, and CUL1’s WHB, ⍺/β, and 4HB domains.
See also Figure S5.
