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. 2023;14(3):209–216. doi: 10.5847/wjem.j.1920-8642.2023.057

Figure 2.

Figure 2

mtDNA-mediated inflammation decreased after inhibiting Drp1-mediated mitochondrial fission. A-C: concentrations of IL-6, TNF-α, and IL-1β from mice measured by ELISA; D: the relative levels of mtDNA in plasma from mice; E-G: representative immunoblots and quantitative histogram of TLR9 and p-P65/P65 in the lung tissues from mice. n=6; *P<0.05, **P<0.01. All values are expressed as the mean±standard deviation. mtDNA: mitochondrial DNA; PQ: paraquat; TLR9: Toll-like receptor 9; P65: NF-κB p65; p-65: (P)-NF-κB p65; GAPDH: glyceraldehyde-3-phosphate dehydrogenase;ns: not significant.