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Large-scale gene rearrangement in the Rv0678 gene
De-novo assembly with the PacBio SMRT Link software indicated a 2·7 Mb inversion (grey box) affecting Rv0678 (ie, splitting Rv0678 into halves; blue box), at positions 779 073 (coding sequence; amino acid 28 in Rv0678; marked by a blue arrow) and 3 552 584 (intergenic region; marked by an orange arrow), flanked by transposase related genes (orange and yellow boxes).
