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Structural mechanisms of bedaquiline resistance
(A) Rv0678 dimer with resistant (orange) and susceptible (blue) mutations shown. The pullout highlights the resistant mutations in the ligand binding pocket. (B) Rv0678 dimer modelled onto DNA, with conserved multiple antibiotic resistance regulator (MarR) family DNA binding elements. (C) Resistant mutations occur across the hydrophobic dimerisation domain.
