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. 2022 Aug 9;48(6):877–886. doi: 10.1038/s41386-022-01412-3

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© The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 2 — A Sample traces of miniature excitatory postsynaptic current (mEPSC) recorded from Cdkl5^+/y neurons (A, upper part) and Cdkl5^-/y neurons (B, upper part) and after the application of DHPG (A, B lower part). C, D Bar graphs showing the mean average amplitude (C) and the inter-event interval (IEI) of mEPSCs (D). E Bar graphs displaying the % of IEI variation IEI after the application of DHPG (100 µM). F Representative traces of currents obtained with patch-clamp recordings on S1 neurons cultures from Cdkl5^+/y and Cdkl5^-/y embryos after NMDA (50 µM) application (upper part), bar graphs showing differences of I_NMDA current between genotypes (lower part). G Representative traces of NMDA currents on S1 neurons after 2-min application of DHPG (100 µM-upper part); bar graphs showing the % change of I_NMDA after the application of DHPG (lower part). H Representative traces of NMDA after 2-min CDPPB + NMDA application (upper part), bar graphs showing the % change of I_NMDA current after the application of CDPPB (lower part). Student’s t-test, chi-square, two-way ANOVA followed by Fisher’s multiple comparison test, *p < 0.05, **p < 0.01, ***p < 0.001 (mEPSC Cdkl5^+/y n = 22 cells, Cdkl5^-/y n = 28; minis+DHPG Cdkl5^+/y: n = 12 cells; minis+DHPG Cdkl5^-/y: n = 13 cells. NMDA: Cdkl5^+/y n = 36 cells, Cdkl5^-/y n = 23 cells; NMDA + DHPG Cdkl5^+/y n = 15 cells and NMDA + DHPG Cdkl5^-/y n = 14 cells; NMDA + CDPPB Cdkl5^+/y n = 12 cells; NMDA + CDPPB Cdkl5^-/y n = 9 cells).