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. 2023 May 3;14:2533. doi: 10.1038/s41467-023-38148-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Incubations were performed for 30 min. at the indicated concentrations of glucose, and secreted insulin measured using an electrochemiluminescence assay. a ***p = 3.19·10^-14 for the effects of 17 mM vs 3 mM glucose. b ^##p = 0.0074 for the effects of 17 mM vs 3 mM glucose and ***p < 2.2·10^-16 for the effects of 50 nM GLP-1 vs 17 mM glucose. c **p = 0.0053 for the effects of 50 nM GLP-1 vs 17 mM glucose and ^##p = 0.0097 for the effects of 17 vs 3 mM glucose. Comparisons by one-way ANOVA in each case. Data points n = 7 replicates per treatment using islets from 16 mice (a, b) or those from individual human subjects (n = 4; c). Error bars represent means ± S.D. Other details are given in the Methods Section. Source data are provided as a Source Data file.