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. 2023 Mar 27;33(5):389–402. doi: 10.1038/s41422-023-00795-2

Fig. 4. Potential predictive biomarkers of treatment efficacy.

Fig. 4

a A sketch map showing the subtype-based comprehensive study of FUSCC TNBC precision medicine. b Genomic landscape of refractory TNBC patients. c An exploratory forest plot of PFS in each arm and genes significantly affecting PFS are shown. Somatic mutations significantly affecting PFS were found only in arms C and E. Specific somatic mutations and unstratified hazard ratios with 95% CIs for PFS were obtained by univariate Cox hazard analysis. FUSCC Fudan University Shanghai Cancer Center, TNBC triple-negative breast cancer, LAR luminal androgen receptor, IM immunomodulatory, BLIS basal-like immunesuppressed, MES mesenchymal-like, CR complete response, PR partial response, SD stable disease, PD progressive disease, PFS progressionfree survival, HR hazard ratios, CI confidence interval, WT wild-type, MT mutation.