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. 2023 May 3;14:2550. doi: 10.1038/s41467-023-38281-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Atomic models of TRPC5_Class1-Gα_i3 (a) and TRPC5_Class2-Gα_i3 (b) viewed from the side. Conformational changes in the coiled-coil domain [(c) and (d)], ankyrin repeat domain (c) and the connecting helix (d) between TRPC5_Class1-Gα_i3 and TRPC5_Class2-Gα_i3. The superimposed models were viewed from the bottom (c) and the side (d). Gα_i3 subunits are omitted for clarification. ARD, ankyrin repeat domain; CCD, coiled-coil domain; CH, connecting helix. Cartoon views of CCD and ARD of TRPC5_Class1-Gα_i3 (f), TRPC5_Class2-Gα_i3 (g), and their superposition (e).