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. 2023 May 3;14:2558. doi: 10.1038/s41467-023-38168-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The noz and ncd gene clusters encode LL-cWW (3) production²⁷, with CDPSs NozA and NcdA each catalyzing the assembly of 3 from Trp-tRNA^Trp³⁰. The noz2 cluster encodes tailoring enzymes that transform 3 into nocardioazine B (2). b The noz, ncd, and noz2 clusters are from different loci of the chromosome. c The biosynthetic pathway yielding 2 is proposed in the current study. (SAM S-adenosyl-L-methionine; DMAPP dimethylallyl pyrophosphate).