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. 2023 Apr 20;11:1147676. doi: 10.3389/fcell.2023.1147676

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Copyright © 2023 Zhang, Zhang, Liao and Tsai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KRAS mutation in PDAC glutamine metabolic reprogramming. KRAS mutation-containing pancreatic cancer cells have great demand for glutamine; this is also termed as “glutamine addition”. Red arrow: The expression of related gene is upregulated. Blue arrow: The expression of related gene is downregulated.