KRAS-WT
|
the wild type of KRAS |
KRAS-MUT
|
the mutation of KRAS |
GAP
|
GTPase activating protein |
GDP
|
Guanine ribonucleoside diphosphate |
GTP
|
Guanine ribonucleoside triphosphate |
GEF
|
Guanine nucleotide exchange factor |
PI3K
|
Phosphatidylinositol 3-kinase |
AKT
|
protein kinase B |
mTOR
|
Mechanistic target of rapamycin |
RAF
|
Serine/threonine protein kinase |
MEK
|
Mitogen-activated protein kinase kinase |
ERK
|
extracellular signal-regulated kinase |
RALA/RALB
|
v-ral simian leukemia viral oncogene homolog A/B |
PLC
|
phospholipase C |
PDK1
|
pyruvate dehydrogenase kinase |
MYC
|
myelocytomatosis oncogene |
CDK5
|
Cyclin—dependent Kinase 5 |
YAP
|
Yes-Associated Protein |
JAK
|
Janus Kinase |
STAT3
|
Signal transducer and activator of transcription 3 |
AURKA
|
The mitotic kinase aurora A |
TPX2
|
Targeting protein for xenopus kinesin-like protein 2 |
GATA6
|
Zinc finger transcription factor 6 |
EGFR
|
epi-dermal growth factor |
ALK4
|
Anaplastic lymphoma kinase 4 |
ATDC
|
ataxia capillaries group D complementary gene |
PFKFB3
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
LIF
|
Leukemia inhibitory factor |
GLUT1
|
Glucose transporter 1 |
Nix
|
Alias |
BNIP3a
|
adenovirus E1B 19 kDa interacting protein 3-like |
FBW7
|
F-box and WD repeat domain-containing 7 |
JAK1
|
Ja-nus Kinase 1 |
STAT6
|
Signal transducer and activator of transcription 6 |
cMyc
|
c-myelocytomatosis oncogene |
NOX4
|
NADPH oxidase 4 |
GLUL
|
glutamate-ammonia ligase |
NRF2
|
Nuclear factor erythroid 2-related factor |
PIN1
|
Protein NIMA-interacting 1 |
MDH1
|
malate dehydrogenase 1 |
FGL1
|
Fibrinogen-like 1 |
FGF21
|
Fibroblast growth factor 21 |
HSL
|
Hormone-sensitive lipase |
CXCR2
|
Chemokine (C-X-C motif) receptor 2 |
AP1
|
Jun proto-oncogene |
IL10
|
Interleukin 10 |
TGFβ
|
Transforming growth factor β |
LIPH
|
lipase H |
PD-L1
|
Programmed cell death 1 ligand 1 |