FIGURE 2.

Overview of sirtuins and ferroptosis: Green lines represent promotion effects and red lines represent inhibition effects in the figure. We constructed sirtuins family pathways related to ferroptosis using Adobe illustrator software according to the gene pathways described in the text. Schematic diagram illustrating the distribution of sirtuins family members in the cell, their regulatory mechanisms, as well as functions. Sirtuins regulate ferroptosis by mediating lipid peroxides, ROS levels as well as iron content through different molecular pathways.