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. 2023 Apr 20;14:1061364. doi: 10.3389/fgene.2023.1061364

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Copyright © 2023 He, Wang, Wen, Li, Guo, Fu, Xiong, Wu, Zhu, Gao, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of recurrence and metastasis on patients’ survival in various stages of cancer. (A) Kaplan–Meier survival curves of all patients with primary, recurrent, and metastatic tumors. (B–E) Kaplan–Meier survival curves of patients with primary tumors, recurrent tumors, and metastatic tumors in stages I, II, III, and IV + V. (F) Cox regression analysis of the impact of recurrence and metastasis on each stage patients’ survival. The point represents the risk ratio, and the line segment represents the 95% confidence interval.