Scheme 3.
Synthesis of compounds 11, 13, 16, 20, and 22 with various P1 and P3 group.
Reagents and conditions: (a) (1) TFA, DCM, (2) EDCI, HOBt, pyridine, R1NH2; (b) (1) ceric ammonium nitrate (CAN), MeCN/H2O, (2) amines, AcOH, Pd/C, H2, MeOH.
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