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Synthesis of compounds 12, 14, and 15 with various P5 group.
Reagents and conditions: (a) N2H4·H2O, THF; (b) (1) 2-chloroethyl chloroformate, Et3N, THF, (2) Cs2CO3, NaI, DMF; (c) MsCl, DCM, DIPEA; (d) (1) 3-chloropropanesulfonyl chloride, Et3N, DCM, (2) K2CO3, NaI, DMF; (e) (1) TFA, DCM, (2) R1NH2, EDCI, HOBt, DMF, DIPEA; (f) (1) ceric ammonium nitrate (CAN), MeCN, water, (2) piperidine, H2, Pd/C, AcOH, MeOH.
