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. Author manuscript; available in PMC: 2024 Jan 26.
Published in final edited form as: J Med Chem. 2023 Jan 11;66(2):1484–1508. doi: 10.1021/acs.jmedchem.2c01651

Scheme 1.

Scheme 1.

Synthesis of compound 2, 3, 4, 5, 6, 8, 9, and 10 with various P3 group.

Reagents and conditions: (a) Cu(OAc)2, Et3N, 4A molecular sieve, O2, DCM; (b) (1) HCl/dioxane, (2) HATU, DIPEA, amino acid 29a-h, DMF; (c) (1) HCl/dioxane, (2) Pd/C, H2, THF; (d) HATU, DIPEA, DMF.