Table 2.
Nanomaterials for CAR-T cell generation.
| Nanomaterials | Gene | Model | In vitro or in vivo | |
|---|---|---|---|---|
| Nanomaterials for CAR gene delivery | Cationic polymers | |||
| Polyglutamate | DNA | Leukemia | In vivo (26) | |
| Polymer (β-aminoester) | mRNA | T lymphocytes | In vitro (27) | |
| pHEMA-g-pDMAEMA | DNA or mRNA | Jurkat human T cell line | In vitro (28) | |
| Polymer (β-aminoester) | mRNA | Leukemia | In vivo (29) | |
| Cationic liposomes | ||||
| Imidazole-containing lipids | mRNA | T lymphocytes | In vitro and vivo (30) | |
| Ionizable liposome | mRNA | T lymphocytes | In vitro (31, 32) | |
| Polydopamine nanoparticles for physical transfection of CAR-T cells |
mRNA | Jurkat and human T cells | In vitro (33) | |