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. Author manuscript; available in PMC: 2023 May 4.
Published in final edited form as: Nature. 2022 Aug 11;610(7931):302–307. doi: 10.1038/s41586-022-05167-1

Fig. 1. Photoenzymatic asymmetric cross-electrophile coupling reactions.

Fig. 1.

a, Challenges associated with sp3–sp3 XEC. b, Proposed photoenzymatic asymmetric XEC. c, Two stereocomplimentary ‘ene’-reductases catalyze the model reaction at pH 9.0. Enantiomeric ratio (er) refers to as the ratio of (S)- to (R)-enantiomer. ERED, ‘ene’-reductase; GDH, glucose dehydrogenase; NADP+, nicotinamide adenine dinucleotide phosphate.