Table 1.

Significant and nominal significant results from Mendelian Randomization analysis.

	Exposure	Outcome	β0 (mm/mm2)	Se (mm/mm2)	IVW-derived p value	Cochran’s Q test derived p value	MR-Egger Intercept test derived p value	Leave-one-out analysis
Significant**	Crohn’s Disease	TH of pars orbitalis	-0.003	0.001	4.85×10-04	0.52	0.69	Yes
	IL-6	SA of middle temporal	-28.575	6.482	1.04×10-05	0.66	0.36	Yes
		TH of fusiform	0.008	0.002	8.86×10-05	0.92	0.52	Yes
		TH of pars opercularis	0.009	0.002	2.34×10-04	0.63	0.84	Yes
	IL-6Rα	SA of superior frontal	21.132	5.806	2.73×10-04	0.5	0.28	Yes
		TH of supramarginal	0.003	0.0002	7.86×10-37	1.00	0.88	Yes
Nominal Significant*	Inflammatory Bowel Disease	SA of inferior parietal	-8.162	2.96	0.006	0.82	0.9	Yes
		SA of pars triangularis	3.145	1.316	0.017	0.04	0.6	Yes
		TH of cuneus	0.002	0.001	0.041	0.16	0.47	No
		TH of paracentral	0.002	0.001	0.034	0.15	0.05	No
		TH of pars orbitalis	-0.003	0.001	0.011	0.7	0.89	Yes
		TH of postcentral	0.002	0.001	0.008	0.09	0.12	Yes
		TH of precentral	0.002	0.001	0.029	0.42	0.36	No
	Crohn’s Disease	TH of medial orbitofrontal	-0.002	0.001	0.034	0.15	0.95	No
		TH of paracentral	0.002	0.001	0.02	0.54	0.57	Yes
	Ulcerative Colitis	SA of bankssts	-1.635	0.81	0.043	0.95	0.33	No
		SA of frontal pole	0.678	0.248	0.006	0.67	0.85	Yes
		SA of fusiform	-3.91	1.879	0.037	0.91	0.22	No
		SA of insula	4.164	1.426	0.003	0.65	0.52	Yes
		TH of cuneus	0.002	0.001	0.037	0.98	0.60	No
		TH of fusiform	-0.002	0.001	0.04	0.66	0.56	No
		TH of isthmus cingulate	-0.004	0.002	0.037	0.10	0.44	No
		TH of postcentral	0.002	0.001	0.015	0.65	0.98	Yes
	IL-6	SA of temporal pole	2.635	0.948	0.005	0.92	0.42	Yes
		TH of entorhinal	0.024	0.011	0.032	0.19	0.77	No
		TH of pericalcarine	-0.007	0.003	0.01	0.67	0.40	No
		TH of superior parietal	-0.004	0.002	0.048	0.62	0.97	No
	IL-6Rα	Global SA	-526.336	180.917	0.004	0.67	0.38	No
		SA of fusiform	8.651	3.366	0.01	0.59	0.70	No
		SA of inferior parietal	-11.024	4.829	0.022	0.77	0.96	No
		SA of pars triangularis	2.351	1.039	0.024	0.98	0.64	No
		SA of precuneus	7.251	2.821	0.01	0.87	0.37	No
		SA of superior temporal	3.618	1.386	0.009	0.99	0.52	No
		TH of bankssts	0.004	0.001	0.002	0.84	0.50	No

^**Significant results were described as results from consistency judgments, pleiotropy tests, and leave-one-out analysis. Consistency judgment should meet all of the following judgment criteria: (1) IVW-derived p value< 7.35×10^-4; (2) WM-derived p value< 0.05; (3) WM and MR Egger derived β were in the same direction as the IVW. ^*Nominal results were defined as IVW-derived p value< 0.05. Cochran’s Q test derived P value and MR-Egger intercept test derived P value< 0.05 is significant. “Yes” referred to result that causality was not driven by a specific SNP after leave-one-out analysis. IL-6, interleukin 6; IL-6Rα, interleukin-6 receptor subunit alpha; SA, surface area; TH, thickness. The above brain cortical structure measurements were with global weighted.