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. 2023 Apr 20;14:1169629. doi: 10.3389/fphar.2023.1169629

TABLE 4.

Antimicrobial properties of Tanacetum species.

Plant part Extract/compound Microbial strains Method Standard drug Key results References
T. balsamita
WP EO B. cereus (ATCC 11778) Serial microdilutions Nr MIC = 2 µL/mL Bączek et al. (2017)
B. cereus (15) MIC = 2 µL/mL
B. cereus (X-13) MIC = 4 µL/mL
B. subtilis (ATCC 6633) MIC = 8 µL/mL
S. aureus (ATCC 25923) MIC = 1 µL/mL
S. aureus (A-529) MIC = 4 µg/mL
S. epidermidis (ATCC 12228) MIC = 1 µL/mL
L. monocytogenes (17/11) MIC = 32 µL/mL
E. aerogenes (ATCC 13048) MIC = 8 µL/mL
E. coli (ATCC 25922) MIC = 1 µL/mL
E. coli (O26 152/11) MIC = 8 µg/mL
K. pneumoniae (ATCC 13883) MIC = 8 µL/mL
P. mirabilis (ATCC 35659) MIC = 2 µL/mL
Y. enterocolitica (O3 383/11) MIC = 1 µL/mL
P. aeruginosa (ATCC 27853) MIC = 32 µL/mL
WP EtOH/H2O (40:60, v/v) B. cereus (ATCC 11778) Serial microdilutions Nr MIC = 4 mg/mL
B. cereus (15) MIC = 4 mg/mL
B. cereus (X-13) MIC = 4 mg/mL
B. subtilis (ATCC 6633) MIC = 4 mg/mL
S. aureus (ATCC 25923) MIC = 2 mg/mL
S. aureus (A-529) MIC = 2 mg/mL
S. epidermidis (ATCC 12228) MIC = 1 mg/mL
L. monocytogenes (17/11) MIC = 64 mg/mL
E. aerogenes (ATCC 13048) MIC = 64 mg/mL
E. coli (ATCC 25922) MIC = 64 mg/mL
E. coli (O26 152/11) MIC = 64 mg/mL
K. pneumoniae (ATCC 13883) MIC = 2 mg/mL
P. mirabilis (ATCC 35659) MIC = 32 mg/mL
Y. enterocolitica (O3 383/11) MIC = 2 mg/mL
P. aeruginosa (ATCC 27853) MIC = 16 mg/mL
AP EO B. subtilis (ATCC 465) Disk diffusion Amicasine 30E and Penicillin 10 The EO displayed moderate to significant antibacterial activity, with S. epidermidis, B. pumulis, and B. subtilis being the most prone to the EO (IZ = 35 ± 0.5, 34 ± 0.2, and 31 ± 0.3 mm, respectively, and MIC values of 0.93, 0.93 and 1.87 mg/mL, respectively) Yousefzadi et al. (2009)
B. pumulis (PTCC 1274)
Enterococcus faecalis (ATCC 29737)
S. aureus (ATCC 25923)
S. epidermidis (ATCC 12228)
E. coli (ATCC 25922)
K. pneumoniae (ATCC 10031)
S. aureus (ATCC 6538 P)
B. cereus (ATCC 14579)
E. coli (FV 755-0139)
P. aeruginosa (ATCC 27853)
S. typhimurium (ATCC 14028)
T. vulgare
WP MeOH S. aureus (ATCC 25923) Disk diffusion Ciprofloxacin IZD = 16.5 ± 0.50 mm Ivănescu et al. (2021)
E. coli (ATCC 25922) IZD = −
P. aeruginosa (ATCC 27853) IZD = −
C. albicans (ATCC 90028) IZD = 12.0 mm
C. parapsilosis (ATCC 22019) IZD = 12.0 mm
AP EO E. coli (ATCC 25922) IC50 = 241 ± 13 µg/mL
S. aureus (ATCC 25923) IC50 = 59 ± 5 µg/mL
AP 1,8-Cineole E. coli (ATCC 25922) Disc diffusion and broth microdilution methods Gentamycin and Chloramphenicol IC50 > 200 µg/mL Coté et al. (2017)
S. aureus (ATCC 25923) IC50 > 200 µg/mL
AP α-Humulene E. coli (ATCC 25922) IC50 > 200 µg/mL
S. aureus (ATCC 25923) IC50 > 200 µg/mL
AP α-Terpinene E. coli (ATCC 25922) IC50 > 200 µg/mL
S. aureus (ATCC 25923) IC50 > 200 µg/mL
AP β-Caryophyllene E. coli (ATCC 25922) IC50 > 200 µg/mL
S. aureus (ATCC 25923) IC50 > 200 µg/mL
AP β-Pinene E. coli (ATCC 25922) IC50 > 200 µg/mL
S. aureus (ATCC 25923) IC50 > 200 µg/mL
AP γ-Terpinene E. coli (ATCC 25922) IC50 > 200 µg/mL
S. aureus (ATCC 25923) IC50 = 50 ± 9 µg/mL
AP Caryophyllene oxide E. coli (ATCC 25922) IC50 = 97 ± 2 µg/mL
S. aureus (ATCC 25923) IC50 = 10.4 ± 0.9 µg/mL
AP Camphor E. coli (ATCC 25922) IC50 = 22 ± 1 µg/mL
S. aureus (ATCC 25923) IC50 = 26 ± 3 µg/mL
WP EO B. cereus (ATCC 11778) Serial microdilutions Nr MIC = 1 µL/mL Bączek et al. (2017)
B. cereus (15) MIC = 1 µL/mL
B. cereus (X-13) MIC = 1 µL/mL
B. subtilis (ATCC 6633) MIC = 4 µL/mL
S. aureus (ATCC 25923) MIC = 2 µL/mL
S. aureus (A-529) MIC = 8 µL/mL
S. epidermidis (ATCC 12228) MIC = 0.5 µL/mL
L. monocytogenes (17/11) MIC> 32 µL/mL
E. aerogenes (ATCC 13048) MIC = 4 µL/mL
E. coli (ATCC 25922) MIC = 8 µL/mL
E. coli (O26 152/11) MIC> 32 µL/mL
K. pneumoniae (ATCC 13883) MIC> 32 µL/mL
P. mirabilis (ATCC 35659) MIC> 32 µL/mL
Y. enterocolitica (O3 383/11) MIC = 1 µL/mL
P. aeruginosa (ATCC 27853) MIC> 32 µL/mL
WP EtOH/H2O (40:60, v/v) B. cereus (ATCC 11778) Serial microdilutions Nr MIC = 8 mg/mL
B. cereus (15) MIC = 8 mg/mL
B. cereus (X-13) MIC = 8 mg/mL
B. subtilis (ATCC 6633) MIC = 16 mg/mL
S. aureus (ATCC 25923) MIC = 4 mg/mL
S. aureus (A-529) MIC = 4 mg/mL
S. epidermidis (ATCC 12228) MIC = 4 mg/mL
L. monocytogenes (17/11) MIC = 64 mg/mL
E. aerogenes (ATCC 13048) MIC> 64 mg/mL
E. coli (ATCC 25922) MIC = 64 mg/mL
E. coli (O26 152/11) MIC = 64 mg/mL
K. pneumoniae (ATCC 13883) MIC = 4 mg/mL
P. mirabilis (ATCC 35659) MIC = 16 mg/mL
Y. enterocolitica (O3 383/11) MIC = 2 mg/mL
P. aeruginosa (ATCC 27853) MIC = 32 mg/mL
T. parthenium
Fl, St EO S. aureus (ATCC 6538) Broth microdilution Chloramphenicol IC50 = 250 µg/mL Polatoglu et al. (2010)
S. epidermis (ATCC 12228) IC50 = 500 µg/mL
B. cereus (NRRL B-3711) IC50 = 500 µg/mL
B. subtilis (NRRL B-437) IC50 = 125 µg/mL
E. coli (NRRL B-3008) IC50 = 500 µg/mL
P. aeruginosa (ATCC 27853) IC50 = 500 µg/mL
E. aerogenes (NRRL 3567) IC50 > 500 µg/mL
P. vulgaris (NRRL B-123) IC50 > 500 µg/mL
S. typhimurium (ATCC 1331) IC50 = 500 µg/mL
AP (Fl) EO (flowering) C. amalonaticus (Lio) Disk diffusion Chloramphenicol IZD = 16.5 ± 2 mm Mohsenzadeh et al. (2011)
P. vulgaris (Lio) IZD = 21 ± 5 mm
S. marcescens (PTCC 1330) IZD = 18 ± 4 mm
E. aerugenes (PTCC 10009) IZD = 17 ± 3.5 mm
B. cereus (ATCC 7064) IZD = 18 ± 2 mm
B. megaterium (PTCC 1672) IZD = 29 ± 6 mm
S. aureus (ATCC 6633) IZD = 24 ± 4 mm
AP EO (Pre-flowering) C. amalonaticus (Lio) Disk diffusion Chloramphenicol IZD = 15 ± 3 mm
P. vulgaris (Lio) IZD = 16 ± 4 mm
S. marcescens (PTCC 1330) IZD = 14 ± 2 mm
E. aerugenes (PTCC 10009) IZD = 13 ± 3 mm
B. cereus (ATCC 7064) IZD = 14 ± 2 mm
B. megaterium (PTCC 1672) IZD = 25 ± 3 mm
S. aureus (ATCC 6633) IZD = 18 ± 2.5 mm
AP EO (Post-flowering) C. amalonaticus (Lio) Disk diffusion Chloramphenicol IZD = 13 ± 3.5 mm
P. vulgaris (Lio) IZD = 17 ± 4 mm
S. marcescens (PTCC 1330) IZD = 13 ± 2 mm
E. aerugenes (PTCC 10009) IZD = 13 ± 4 mm
B. cereus (ATCC 7064) IZD = 15 ± 4 mm
B. megaterium (PTCC 1672) IZD = 26 ± 3.5 mm
S. aureus (ATCC 6633) IZD = 22 ± 4 mm
T. hololeucum (Bornm.) Podlech
AP EO S. aureus (ATCC 25923) Disk diffusion Cefexime IZD = 35 mm; MIC = 2 mg/mL Shamkhani et al. (2016)
B. cereus (PTCC 1015) IZD = 14 mm; MIC = 2 mg/mL
E. coli (ATCC 25922) IZD = 12 mm; MIC = 16 mg/mL
K. Pneumoniae (Clinical isolate) IZD = 9 mm; MIC = 16 mg/mL
T. polycephalum
AP EO T. harizanum Broth microdilution Amphotericin B MIC = 312.5 µg/mL; MFC = 312.5 µg/mL Eblaghi et al. (2016)
B. spectabilis MIC = 625.0 µg/mL; MFC = 625.0 µg/mL
P. variotii MIC = 312.5 µg/mL; MFC = 312.5 µg/mL
P. chrysogenum MIC = 1250.0 µg/mL; MFC = 1250.0 µg/mL
A. oryzae MIC = 625.0 µg/mL; MFC = 625.0 µg/mL
A. niger MIC = 1250.0 µg/mL; MFC = 1250.0 µg/mL