Table 2.

Odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer in relation to EarlyCDT^®-Lung test results in different subgroups

	High vs no significant		Moderate vs no significant
	OR (95% CI)	p-value	OR (95% CI)	p-value
Overall	1.09 (0.48–2.47)	0.84	0.89 (0.34–2.30)	0.81
Cohort
EPIC	1.67 (0.61–4.59)	0.32	0.83 (0.25–2.73)	0.76
NSHDS	0.40 (0.08–2.06)	0.27	1.00 (0.20–4.95)	1.00
Sex
Male	0.75 (0.26–2.16)	0.59	0.71 (0.23–2.25)	0.57
Female	2.00 (0.50–8.00)	0.33	1.50 (0.25–8.98)	0.66
Smoking status
Former smokers	1.50 (0.42–5.32)	0.53	2.00 (0.37–10.92)	0.42
Current smokers	0.83 (0.25–2.73)	0.76	0.57 (0.17–1.95)	0.37
Smoking history
<20 pack-years	0.40 (0.08–2.06)	0.27	1.00 (0.14–7.10)	1.00
≥20 pack-years	2.50 (0.49–12.89)	0.27	0.67 (0.19–2.36)	0.53
Sample collection time before diagnosis
≤ 1 year	2.33 (0.60–9.02)	0.22	0.67 (0.11–3.99)	0.66
> 1 year	0.63 (0.20–1.91)	0.41	1.00 (0.32–3.10)	1.00
Age at sample collection
≤ 60 years	0.56 (0.19–1.66)	0.29	1.17 (0.39–3.47)	0.78
>60 years	6.00 (0.72–49.84)	0.10	0.50 (0.05–5.51)	0.57
Age at diagnosis
≤ 60 years	0.67 (0.19–2.36)	0.53	0.80 (0.21–2.98)	0.74
>60 years	1.60 (0.52–4.89)	0.41	1.00 (0.25–4.00)	1.00
Calendar year of sample collection
1988–1995	0.83 (0.25–2.73)	0.76	2.50 (0.49–12.89)	0.27
1996–2016	1.20 (0.37–3.93)	0.76	0.43 (0.11–1.66)	0.22

Abbreviation: EPIC, European Prospective Investigation into Cancer and Nutrition; NSHDS, Northern Sweden Health and Disease Study