Table 3.
Summary of HSF1 expression and function in different types of cancer
| Cancer Type | Effect on tumorigenesis | Mechanism | Reference |
|---|---|---|---|
| Breast Cancer | Promotes glycolysis, cell growth and invasion | HSF1/LDHA axis | 7, 148 |
| Mitogenic action, motility and cell spreading | ERα | 149, 150 | |
| Apoptosis | MicroRNA-615-5p | 151, 152 | |
| Proliferation and migration | FAM3C-YY1-HSF1 axis | 153-156 | |
| Lung Cancer | Apoptosis and tumor growth | EGFR-TKI | 157 |
| Cell survival, tumor growth, proliferation and metastasis | ABL2-HSF1 signaling | 158 | |
| Ovarian Cancer | Proliferation | IgA anti HSF1 | 159, 160 |
| Tumor progression, cell spreading, ECM remodeling and cancer invasion | DKK3; YAP/TAZ | 98, 161, 162 | |
| Endometrial Cancer | Tumor progression | ERα | 163 |
| Prostate Cancer | Tumor progression, cell survival and proliferation | Androgen receptor | 164-167 |