Table 3.

Content comparison of PROMIS CAT with SF-12^a

	PROMIS CAT	SF-12
Type of PROM	Generic	Generic
PRO	HRQOL	HRQOL
Domains	Physical Function	Physical functioning
	Pain Interference	Bodily pain
	Fatigue	Vitality
	Sleep Disturbance	Role-physical
	Anxiety	Role-emotional
	Depression	Mental health
	Ability to Participate in Social Roles and Activities	Social functioning
		General health
		Composite summary scores b :
		PCS
		MCS
Number of items	All PROMIS domainsc	All SF-12 items
	median (IQR): 45 (38–55) items	12 items
	Physical Function	Physical functioning
	median (IQR): 4 (3–6) items	2 items
	Pain Interference	Bodily pain
	median (IQR): 4 (2–12) items	1 item
	Fatigue	Vitality
	median (IQR): 5 (4–6) items	1 item
	Sleep Disturbance	Role-physical
	median (IQR): 10 (8–12) items	2 items
	Anxiety	Role-emotional
	median (IQR): 7 (6–10) items	2 items
	Depression	Mental health
	median (IQR): 8 (5–12) items	2 items
	Ability to Participate in Social Roles and Activities	Social functioning
	median (IQR): 5 (4–6) items	1 item
		General health
		1 item
		Composite summary scores b :
		PCS
		6 items
		MCS
		6 items
Recall period	In general/1 week	In general/4 weeks
Rating scale	5-point scale	3- and 5-point scales
Score (range)	Norm-based scoring	Norm-based scoring
	T-score (roughly 0–100)	(roughly 0–100)
Norm or reference standard	General US population: mean (SD), 50 (10)	General US population: mean (SD), 50 (10)
Score interpretation	Higher scores represent more of the HRQOL domain being measured (e.g. a higher score on fatigue means a worse fatigue, and a higher score on physical function means a better physical function).	Higher scores represent a more favorable HRQOL (e.g. a higher score on bodily pain means less bodily pain, and a higher score on physical functioning means a better physical functioning).
Measurement method	Item Response Theory (IRT)	Classical Test Theory (CTT)
Completion options	Electronic only	Electronic or paper based
Time to completed	All PROMIS CATs	All SF-12 items
	median (IQR): 10.2 (8.3–12.6) min.	median (IQR): 3.3 (2.4–4.6) min.
	Physical Function
	median (IQR): 1.3 (0.8–1.7) min.
	Pain Interference
	median (IQR): 1.2 (0.8–1.8) min.
	Fatigue
	median (IQR): 1.3 (1.0–2.0) min.
	Sleep Disturbance
	median (IQR): 2.0 (1.5–2.6) min.
	Anxiety
	median (IQR): 1.4 (1.0–1.9) min.
	Depression
	median (IQR): 1.3 (1.0–1.8) min.
	Ability to Participate in Social Roles and Activities
	median (IQR): 1.2 (1.0–1.6) min.

^aThe DSI aims to measure a different patient-relevant outcome and is therefore not included in this table. For characteristics of the DSI, see Weisbord 2004 [21] and Van der Willik 2021[43].

^bSF-12 PCS includes the domains physical functioning, role-physical, bodily pain, and general health; SF-12 MCS includes the domains vitality, social functioning, role-emotional, and mental health.

^cNumber of items used as observed in the current study sample at baseline. Additional item details, including the top three most frequently used items of PROMIS CATs, are provided in Supplement B.

^dTime to complete the PROMs as observed in the current study sample at baseline.