Table 2:

Screening characteristics of instruments assessing depressive symptoms using a PHQ-9 score ≥10 to identify potentially clinically significant (moderate to severe) depressive symptoms.

Tool	Cut-off scores	Sensitivity	Specificity	TP	TN	FP	FN	PPV	NPV
ESASr-D	≥1	0.75	0.72	67	283	108	22	0.38	0.93
	≥2	0.71	0.84	63	327	64	26	0.50	0.93
PHQ-2	≥1	0.98	0.67	87	261	130	2	0.40	0.99
	≥2	0.92	0.81	82	315	76	7	0.52	0.98
PROMIS-D	≥53	0.82	0.77	73	301	90	16	0.45	0.95
	≥55	0.73	0.85	65	333	58	24	0.53	0.93
PHQ-2 and PROMIS-D	≥1 and ≥53	0.81	0.84	72	327	64	17	0.53	0.95
	≥2 and ≥53	0.78	0.88	69	346	45	20	0.61	0.95
	≥1 and ≥55	0.72	0.87	64	342	49	25	0.57	0.93
	≥2 and ≥55	0.69	0.91	61	357	34	28	0.64	0.93

TP, true positive; TN, true negative; FP, false positive; FN, false negative; PPV: positive predictive value; NPV: negative predictive value.

Rows in bold indicate screening combinations with both sensitivity and specificity ≥0.80.