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. Author manuscript; available in PMC: 2023 May 4.
Published in final edited form as: Nat Chem Biol. 2021 May 25;17(6):632–640. doi: 10.1038/s41589-021-00798-3

Table 1.

Enzymatic inhibitors and their applications in cell division studies.

Inhibitors Function Applications in cell division
5-Iodotubercidin Haspin inhibitor Deplete centromeric Aurora B pool56.
Apcin APC/C inhibitor Prolong or shorten metaphase at low or high SAC activity, respectively70,71.
Centrinone Plk4 inhibitor Modulate centriole numbers18, generate asymmetric spindles19,20.
FCPT
BRD9876		 Eg5 rigor inhibitor Spindle crosslinking40, block poleward microtubule flux38,39, reduce inter-kinetochore tension11.
GSK923925 CENP-E rigor inhibitor Generate pole-proximal chromosomes7,61.
GW108X KIF15 inhibitor Deplete spindle-bound KIF1542.
KIF15-IN-1 KIF15 rigor inhibitor Reduce inter-kinetochore tension11.
MLN8054
MLN8237		 Aurora A inhibitor Inhibit Aurora A activity after mitotic entry61,62.
proTAME APC/C inhibitor Prolong metaphase69.
Reversine MPS1 inhibitor Shorten metaphase and generate segregation errors65.