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. Author manuscript; available in PMC: 2023 May 4.
Published in final edited form as: Nat Chem Biol. 2021 May 25;17(6):632–640. doi: 10.1038/s41589-021-00798-3

Table 2.

Chemical dimerizers and their applications in cell division studies.

Dimerizers Function Applications in cell division
AP20187 FKBP homo-dimerization Dimerize MPS1 for trans-activation75.
Auxin/IAA Degrade AID-tagged protein by recruiting ubiquitin ligases Rapidly deplete proteins without known inhibitors82.
CTH Light-inducible dimerization of eDHFR and Halo enzyme Recruit kinesin motors7 or Aurora B11 to kinetochores.
LoKI Inhibit kinases proximal to the SNAP-tagged protein Inhibit pole- or kinetochore-localized pools of Aurora A and Plk187.
Rapamycin FKBP-FRB dimerization Recruit Aurora B to centromeres58 or MAD1 to kinetochores72,73, test MPS1 function at different locations76,89.
TNH Photo-cleavable dimerizer linking eDHFR and Halo enzyme Initiate mitotic exit by releasing MAD1 from kinetochores7.