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. 2023 May 4;14:72. doi: 10.1186/s40104-023-00867-8

Table 7.

Effects of tannic acid on the serum immune indices of chickens with NE

NC PC PTA1 PTA2 PTA3 PTA4 P-value1 L2 Q2
d 28
 IgA, mg/mL 0.28 ± 0.04 0.34 ± 0.05 0.29 ± 0.03 0.30 ± 0.02 0.33 ± 0.03 0.28 ± 0.011 0.630 0.305 0.851
 IgM, mg/mL 0.08 ± 0.01c 0.16 ± 0.02ab 0.15 ± 0.01ab 0.18 ± 0.03ab 0.21 ± 0.02a 0.15 ± 0.01b 0.001 0.807 0.163
 Serum-specific IgY antibody, OD 450 nm 2.79 ± 0.05b 2.92 ± 0.03a 2.87 ± 0.02ab 2.85 ± 0.05ab 2.79 ± 0.04b 2.78 ± 0.03b 0.090 0.003 0.637
 CRP, μg/mL 6.53 ± 0.76c 13.97 ± 1.28a 12.64 ± 1.20ab 12.78 ± 0.70ab 11.50 ± 0.63ab 10.77 ± 1.04b  < 0.001 0.024 0.952
 MPO, pg/mL 697.06 ± 65.48c 1,291.64 ± 99.90a 1,305.64 ± 109.51a 1,132.20 ± 86.60ab 1,008.71 ± 103.05b 968.49 ± 76.27b  < 0.001 0.004 0.872
 sIgA, μg/mg prot 30.42 ± 3.58b 52.52 ± 8.21a 34.88 ± 3.78b 35.13 ± 4.43b 28.96 ± 3.19b 28.07 ± 2.76b 0.008 0.001 0.149
d 35
 IgA, mg/mL 0.38 ± 0.04 0.37 ± 0.05 0.36 ± 0.08 0.36 ± 0.08 0.35 ± 0.04 0.31 ± 0.03 0.972 0.497 0.737
 IgM, mg/mL 0.08 ± 0.01 0.08 ± 0.02 0.07 ± 0.02 0.08 ± 0.04 0.06 ± 0.003 0.05 ± 0.05 0.903 0.332 0.724
 Serum-specific IgY antibody, OD 450 nm 2.87 ± 0.04 2.88 ± 0.03 2.92 ± 0.02 2.88 ± 0.03 2.88 ± 0.02 2.90 ± 0.03 0.903 0.964 0.993
 CRP, μg/mL 9.02 ± 0.65c 14.00 ± 0.36a 11.27 ± 0.66b 10.16 ± 0.70bc 9.48 ± 0.87bc 8.59 ± 0.80c  < 0.001  < 0.001 0.128
 MPO, pg/mL 765.28 ± 50.28c 1,570.16 ± 46.42a 1,009.84 ± 60.30b 973.55 ± 65.72b 871.87 ± 53.66bc 852.16 ± 57.78bc  < 0.001  < 0.001  < 0.001
 sIgA, μg/mg prot 33.02 ± 4.45 38.44 ± 4.10 36.82 ± 2.67 35.72 ± 4.90 31.56 ± 3.13 29.74 ± 1.27 0.531 0.046 0.792

n = 7. Data are presented as mean ± SEM. NC No tannic acid treatment or NE infection, PC NE infection + 0 mg/kg tannic acid, PTA1 NE infection + 250 mg/kg tannic acid, PTA2 NE infection + 500 mg/kg tannic acid, PTA3 NE infection + 750 mg/kg tannic acid, PTA4 NE infection + 1,000 mg/kg tannic acid, L Linear, Q Quadratic

1Overall P-values obtained from ANOVA; 2P-values obtained using contrast trend analysis. a–cDifferent lower-case letters in the same column indicate significant differences (P < 0.05)