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. 2023 May 4;18:48. doi: 10.1186/s13020-023-00750-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Metabolic profilings of serum and urine samples from AIA-Cold and AIA-Hot rats. A PCA and PLS-DA score plots of metabolic profilins of serum and urine samples from AIA-Cold and AIA-Hot rats. B Number of differential metabolites in rat urine and serum samples of AIA-Cold and AIA-Hot groups. C Differential metabolites Venn diagram, different colors represent different combinations of comparisons. D–G Enrichment bubble plots based on differential metabolites in rat urine and serum samples of AIA-Cold and AIA-Hot groups. H, I Sankey dot plots of the representative metabolic pathways of AIA-Cold and AIA-Hot, with differential metabolites involved in the pathway on the left, and fold-change (FC)-related bubble plots of the metabolic pathways on the right