Table 2.

Regulation of mRNAs by m6A modifications

Function	M6A regulatory proteins	Mechanism	References
mRNA processing	FTO	regulate exon splicing of the adipogenesis regulator RUNX1T1 by modulating m6A levels around the splicing site, thus regulating differentiation	82
	YTHDC1	promote the RNA-binding ability of SRSF3 and inhibit that of SRSF10 to regulate mRNA splicing	62
		interact with SRSF3 and RNA nuclear export factor 1 to regulate mRNA nuclear export	83
Degradation and translation of mature mRNA	METTL3	mediate m6A modification of SOX2 mRNA to increase transcription stability	84
	YTHDF1	enhance translation efficiency of its target RNA	60
	IGF2BP1/2/3	regulate the translation of m6A-modified mRNA	67
	YTHDC2	enhance translation efficiency and reduce the stability of its target mRNA by interacting with translation and decay mechanisms	85