Table 3.

Biological functions and role of m6A regulatory proteins in human diseases

Functions	m6A regulatory proteins	Mechanisms	References
Spermatogenesis disorders	METTL3	Altered splicing of spermatogenesis-related genes, thus regulating spermatogonial differentiation	89
	METTL3 and METTL14	Regulation of spermatogonial stem cells and spermatogenesis disorders	88
	ALKBH5	Regulated nuclear export of RNA and sperm malformation in mice	90
Central nervous system diseases	METTL3	Regulated mice cerebellar development	91
	METTL14	Regulated mice cerebral cortex development	92
	FTO	Regulated mice memory	94
Cardiovascular diseases	METTL3	Contributed to cardiac hypertrophy	97
		Promoted the maturation of miR-34a, which in turn inhibits SIRT1 and promotes the formation of abdominal aortic aneurysm	99
	FTO	Participated in reduced cardiomyocyte contractile function during heart failure	98
Tumors	METTL3	Promoted the maturation of miR-25-3p, thus activating the Akt-P70S6K pathway and promoting the initiation and development of PDAC	100
	FTO	Promoted glycolysis of breast cancer cells through the PI3K/AKT pathway	101
		Upregulated PKM2 exression through the demethylation of PKM2, thereby regulating glucose metabolism of HCC	102