Table 4.
Regulation of ncRNAs by m6A modifications
| ncRNA | M6A regulatory proteins | Mechanisms | References |
|---|---|---|---|
| miRNAs | METTL3 | a. Marked pri-miRNA through m6A b. Increased Dicer splicing of pre-miRNAs |
106 |
| HNRNPA2B1 | Binded to m6A in pri-miRNA to recruit DGCR8, thereby promoting the maturation of miRNAs | 65 | |
| LncRNAs | HNRNPC and HNRNPG | Binded RNA sequences surrounding m6A in lncRNA MALAT1 | 64, 108 |
| — | Played a role in the lncRNA-miRNA interaction, thereby influencing miRNA level | 109 | |
| circRNAs | METTL3 and METTL14 | Enhanced m6A-driven circRNA translation | 110 |
| FTO | Inhibited m6A-driven circRNA translation | ||
| YTHDF3 and eIF4G2 | Played key roles in m6A-driven circRNA translation | ||
| YTHDF2 | Differentiated endogenous circRNA from exogenous circRNA and regulate innate immunity | 111, 112 |