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. 2023 Apr 9;19(7):2114–2131. doi: 10.7150/ijbs.82177

Table 1.

Top10 upregulated pathway in cluster 3 with key enzymes of each pathway.

pathway pathway_name key_enzyme
hsa00071 Fatty acid degradation - Homo sapiens (human) ACADM, ACADL, CPT1A, CPT1B, CPT1C
hsa00120 Primary bile acid biosynthesis - Homo sapiens (human) CYP7A1, CYP8B1, CYP27A1
hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) BCAT1, BCAT2, BCKDHA,
hsa00350 Tyrosine metabolism - Homo sapiens (human) TYR, TAT
hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human) UGDH
hsa00380 Tryptophan metabolism - Homo sapiens (human) TDO2, IDO1, IDO2, KMO
hsa00220 Arginine biosynthesis - Homo sapiens (human) ASS1, ARG1, ARG2, ASL
hsa00650 Butanoate metabolism - Homo sapiens (human) ACAT1, ACAT2
hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) SHMT1, SHMT2
hsa00410 beta-Alanine metabolism - Homo sapiens (human) GAD1, GAD2, GADL1