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. 2022 Nov 4;25(5):871–885. doi: 10.1093/neuonc/noac245

Figure 4.

Figure 4.

ARL13B interacts with VEGFR2. (A) The colocalization of ARL13B and VEGFR2 in primary cilium. (B) GST-fusion protein-protein interaction assays revealed the interaction between ARL13B and VEGFR2. (C) ARL13B binds VEGFR2. Arrowheads indicate target proteins. (D) Co-IP-IB assays with indicated antibodies to detect the ARL13B-VEGFR2 interaction in mammalian cells. (E) The endogenous ARL13B-VEGFR2 interaction in endothelial cells was determined by co-IP-IB assay. (F) Diagrammatic representation of VEGFR2 and various truncated mutants used for mapping the ARL13B-binding domain. (G) GST-fusion protein-protein interaction assays were conducted to map the ARL13B-binding domain of VEGFR2. Asterisks indicate domains that interact with ARL13B.