Extended Data Fig. 9 |. SRP-2001 reduces progerin transcripts in multiple mesenchyme-derived murine tissues.
Quantitative PCR analysis of transgene transcripts in a, quadriceps, b, femoral bone, and c, kidneys of LMNAG/G mice receiving long-term treatment with saline (vehicle) or 60 mg/kg SRP-2001. Expression of LMNA (A), progerin (P) and LMNC (C) is quantitated relative to Hprt expression, as a fraction of all transgene-derived LMNA transcripts or relative to transgene-derived LMNC transcripts. Data are presented as mean values ± SD determined from 12 independent samples per treatment group (n = 6 males, 6 females). * p < 0.05; ** p < 0.01; *** p < 0.001 vs same transcript or protein in mice receiving saline only (vehicle).