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. Author manuscript; available in PMC: 2023 May 4.
Published in final edited form as: Nat Med. 2021 Mar 11;27(3):536–545. doi: 10.1038/s41591-021-01274-0

Fig. 5 |. Long-term treatment of HGPS mice with SRP-2001 significantly extends their lifespan.

Fig. 5 |

LMNAG/G mice received twice weekly treatments via intravenous tail injection at 60 mg kg−1 beginning at 2 weeks of age. a, Left: 7.5-month-old LMNAG/G mouse treated with SRP-2001. Right: 7.5-month-old LMNAG/G mouse receiving saline (vehicle). b, Growth curves of LMNAG/G mice treated with SRP-2001 or saline (vehicle) compared to C57BL/6 WT mice. Values and error bars represent the mean ± s.d. for n = 6 mice per treatment group. c, Kaplan–Meier plots for saline-treated controls (black line, n = 12) and SRP-2001-treated mice (blue line, n = 12) illustrate the 61.6% increase in lifespan of the treated group, from a median of 30.5 weeks to a median of 49.5 weeks (P < 0.0001).