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. 2023 May 2;24(1):2203332. doi: 10.1080/15384047.2023.2203332

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — FLOT1 depletion boosted DNA damage activated STING signaling pathway. (a) Western blotting analysis of γH2A× at the indicated time points in A549 Plvx-FLOT1 and Plvx-Control group cells. (b) Western blotting analysis of γH2A× at the indicated time points in A549 cell and A549/X sh-FLOT1 and sh-Control group cells after 6 Gy radiation. (c) Western blotting analysis of FLOT1, STING, Phospho-STING, TBK1, and Phospho-TBK1 in A549 and H520 cells after 6 Gy radiation. (d) Western blotting analysis of STING, Phospho-STING, TBK1, and Phospho-TBK1 in A549 Plvx-FLOT1 and Plvx-Control groups after 6 Gy radiation. (e) Western blotting analysis of FLOT1, STING, Phospho-STING, TBK1, and Phospho-TBK1 in A549/X sh-FLOT1 and sh-Control groups after 6 Gy radiation. (f) The mRNA expression of CCL5, CXCL10, and IFNβ wasdetected by Qrt-PCR in A549/X cells with or without FLOT1 depletion after radiation. Each experiment was performed in triplicate, and the values were presented as the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.