Table 1.
Correlations between baseline characteristics, radiotherapy response, and FLOT1 expression in patients with NSCLC.
| Characteristic | Overall | FLOT1 Expression(N = 10) |
p Value | |
|---|---|---|---|---|
| High(2) | Low/None(8) | |||
| Age, y | 0.236 | |||
| ≥65 | 8 | 1 | 7 | |
| <65 | 2 | 1 | 1 | |
| Sex | 0.429 | |||
| Male | 8 | 2 | 6 | |
| Female | 2 | 0 | 2 | |
| Smoking Status | - | |||
| Smoker | 0 | 0 | 0 | |
| Never smoked | 10 | 2 | 8 | |
| Histological type | 0.153 | |||
| ADC | 4 | 2 | 2 | |
| SQCC | 4 | 0 | 4 | |
| Other | 2 | 0 | 2 | |
| T stage | 0.534 | |||
| T1 | 3 | 0 | 3 | |
| T2 | 4 | 1 | 3 | |
| T3 | 2 | 1 | 1 | |
| T4 | 1 | 0 | 1 | |
| N stage | 0.076 | |||
| N0 | 4 | 0 | 4 | |
| N1 | 2 | 1 | 1 | |
| N2 | 3 | 0 | 3 | |
| N3 | 1 | 1 | 0 | |
| N4 | 0 | 0 | 0 | |
| Stage | 0.335 | |||
| I | 4 | 0 | 4 | |
| II | 2 | 1 | 1 | |
| III | 0 | 0 | 0 | |
| IV | 4 | 1 | 3 | |
| PD-L1 Expression | 0.766 | |||
| IHC 0 | 4 | 1 | 3 | |
| IHC 1 | 2 | 0 | 2 | |
| IHC 2 | 1 | 0 | 1 | |
| IHC 3 | 3 | 1 | 2 | |
| Efficacy | ||||
| PR | 5 | 0 | 5 | |
| SD | 3 | 0 | 3 | |
| PD | 2 | 2 | 0 | |
| ORR | 5 | 0 | 5 | 0.114 |
| DCR | 8 | 0 | 8 | 0.002 |
Abbreviations: IHC, immunohistochemistry; ADC, adenocarcinoma; SQCC, squamous cell carcinoma; PR, partial response; SD, Stable disease; PD, progressive disease; ORR, objective response rate; DCR, disease control rate.