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. 2023 May 2;15(1):2206507. doi: 10.1080/19490976.2023.2206507

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — TLR family genes are upregulated in intestinal eosinophils of offspring born from mice fed with propionate (a) Expression levels of Gpr41 mRNA were evaluated by qPCR in eosinophils, B cells, CD4⁺ T cells, and CD8⁺ T cells isolated by FACS from small intestinal lamina propria (SILP) and lung cells of wild-type C57BL/6 mice. (b) Schematic depiction of the experimental protocols for isolation of mRnas used in (c-e). (c) Heatmap of differentially expressed genes (DEGs) between the Propionate group and Control water group and a list of the genes upregulated (middle) and downregulated (right) in the Propionate group. (d) Bar plots of the combined score for gene ontology (GO) term enrichment in GO biological processes for DEGs between the propionate group and the Control water group. (e) Expression levels of Tlr2, Tlr8 and Trl9 mRNA in wild-type and GPR41 knockout SILP eosinophils were evaluated by qPCR. Data are mean ± SD. **p < 0.01 by Student’s t-test. (f) Expression levels of Tlr2, Tlr8 and Trl9 mRNA in lung eosinophils were evaluated by qPCR. Data are mean ± SD. *p < 0.05 and **p < 0.01 by Student’s t-test.