Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 20;16:1153870. doi: 10.3389/fnmol.2023.1153870

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Wu, Shang, Wang, Wang, Zuo, Lian, Liu, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Downregulation of cingulate PRMT1 is necessary to develop peripheral hypersensitivity. (A) Upper schematics of AAV8 vectors engineered to overexpress PRMT1 and an eGFP Ctrl. Lower experimental paradigm for behavioral testing. (B) Illustration of bilateral AAV8-Prmt1 OE virus in the mouse ACC. (C) PWT tests conducted in both sham and CPN-ligated mice injected either Prmt1 Ctrl or OE virus in ACC (Sham Prmt1 Ctrl, n = 9; Sham Prmt1 OE, n = 8; CPN Prmt1 Ctrl, n = 9; CPN Prmt1 OE, n = 8, Two-way RM ANOVA, interaction: F_(15;150) = 2.0, p < 0.05, Time: F_(5;150) = 2.70, p < 0.05, Prmt1 Ctrl vs. Prmt1 OE: F_(3;150) = 15.60, p < 0.01). (D) PWTs measured in both saline-and CFA-injected mice either with Prmt1 Ctrl or OE virus in ACC (Saline Prmt1 Ctrl, n = 6; Saline Prmt1 OE, n = 6; CFA Prmt1 Ctrl, n = 8; CFA Prmt1 OE, n = 10, Two-way RM ANOVA, interaction: F_(15;130) = 3.40, p < 0.01, Time: F_(5;130) = 4.72, p < 0.01, Prmt1 Ctrl vs. Prmt1 OE: F_(3;130) = 11.41, p < 0.01). Data are represented as mean ± SEM; ns, not significant.