Table 4.

Multivariate analyses for overall, disease-free and progression-free survival^*

Variable	Overall survival		Disease-free survival		Progression-free survival
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Age, yr	0.993 (0.979–1.007)	0.31	1.022 (0.994–1.051)	0.12	1.002 (0.979–1.025)	0.90
Female v. male sex	1.066 (0.748–1.520)	0.72	0.751 (0.379–1.489)	0.41	1.306 (0.779–2.190)	0.31
Locally advanced v. early stage†	3.291 (1.887–5.738)	< 0.001	4.313 (1.813–10.259)	< 0.001	—	—
Rural or remote v. urban or suburban residence	0.622 (0.383–1.010)	0.06	0.472 (0.186–1.200)	0.12	0.536 (0.250–1.149)	0.11

CI = confidence interval; HR = hazard ratio.

^*Clinical variables with a statistically significant difference between groups in univariate analysis were included in this model.

^†Not applicable for progression-free survival since all patients had locally advanced cancer.