12. NMA results for PFS (all risk groups combined).

Results of network meta‐analysis for outcome progression‐free survival (combined risk groups). Treatments are ordered by P‐Score (descending). Only subnetworks with >1 designs. Upper triangle: direct estimate. Lower triangle: network estimate. Subnet 1 No. of studies: 27. No. of pairwise comparisons: 27. No. of treatments: 23. No. of designs: 23. Qtotal= 6.93, df=5, P = 0.23; Qwithin= 2.02, df = 4, p=0.73; Qbetween=4.91, df = 1, P = 0.027; I²=27.9%, Tau² = 0.0155 Treatment Effects + 95%‐CIs (Hazard ratios, random‐effects model):

LEN+PEM

.

.

.

.

.

0.39 [0.29, 0.53]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.73 [0.46, 1.16]

CAB

.

.

.

.

0.54 [0.37, 0.76]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.60 [0.39, 0.91]

0.82 [0.52, 1.31]

LEN+EVE

.

.

.

0.65 [0.48, 0.87]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.57 [0.38, 0.86]

0.79 [0.50, 1.23]

0.96 [0.64, 1.42]

PEM+AXI

.

.

0.68 [0.52, 0.89]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.45 [0.31, 0.65]

0.61 [0.40, 0.93]

0.74 [0.51, 1.08]

0.78 [0.55, 1.10]

ATE+BEV

.

0.87 [0.70, 1.10]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.44 [0.29, 0.65]

0.60 [0.39, 0.94]

0.73 [0.49, 1.09]

0.76 [0.53, 1.11]

0.98 [0.69, 1.39]

NIV+IPI

0.89 [0.68, 1.16]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.39 [0.29, 0.53]

0.54 [0.37, 0.76]

0.65 [0.48, 0.87]

0.68 [0.52, 0.89]

0.87 [0.70, 1.10]

0.89 [0.68, 1.16]

SUN

0.95 [0.73, 1.23]

.

.

0.89 [0.53, 1.50]

.

.

0.84 [0.55, 1.28]

.

.

0.71 [0.55, 0.92]

0.79 [0.60, 1.04]

.

0.57 [0.22, 1.47]

0.54 [0.41, 0.71]

.

.

0.37 [0.25, 0.55]

0.51 [0.33, 0.79]

0.62 [0.42, 0.92]

0.65 [0.45, 0.94]

0.83 [0.59, 1.17]

0.85 [0.58, 1.23]

0.95 [0.73, 1.23]

PAZ

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.40 [0.25, 0.63]

0.36 [0.22, 0.60]

0.50 [0.29, 0.86]

0.60 [0.36, 1.00]

0.63 [0.38, 1.03]

0.81 [0.50, 1.30]

0.82 [0.50, 1.35]

0.93 [0.61, 1.40]

0.97 [0.60, 1.59]

TIV

.

.

.

.

.

.

.

.

0.76 [0.54, 1.06]

.

.

.

.

.

0.35 [0.21, 0.61]

0.49 [0.27, 0.86]

0.59 [0.35, 1.01]

0.62 [0.37, 1.04]

0.79 [0.48, 1.31]

0.81 [0.48, 1.36]

0.91 [0.58, 1.42]

0.95 [0.57, 1.60]

0.98 [0.59, 1.63]

AXI

.

.

.

.

.

.

.

0.77 [0.53, 1.12]

.

.

.

.

.

0.35 [0.19, 0.63]

0.48 [0.25, 0.90]

0.58 [0.32, 1.05]

0.61 [0.34, 1.09]

0.78 [0.44, 1.37]

0.79 [0.44, 1.42]

0.89 [0.53, 1.50]

0.94 [0.53, 1.67]

0.96 [0.50, 1.87]

0.98 [0.50, 1.95]

NIN

.

.

.

.

.

.

.

.

.

.

.

.

0.33 [0.21, 0.53]

0.46 [0.28, 0.76]

0.56 [0.35, 0.88]

0.58 [0.37, 0.91]

0.75 [0.49, 1.14]

0.76 [0.49, 1.18]

0.85 [0.60, 1.22]

0.90 [0.58, 1.39]

0.92 [0.55, 1.54]

0.94 [0.55, 1.62]

0.96 [0.51, 1.79]

IFN+BEV

.

.

0.92 [0.65, 1.29]

0.91 [0.69, 1.20]

.

.

.

.

0.71 [0.55, 0.92]

0.63 [0.48, 0.83]

.

0.32 [0.01, 17.44]

0.44 [0.01, 24.04]

0.54 [0.01, 29.06]

0.56 [0.01, 30.33]

0.72 [0.01, 38.92]

0.73 [0.01, 39.70]

0.83 [0.02, 44.22]

0.87 [0.02, 46.82]

0.89 [0.02, 48.10]

0.91 [0.02, 49.16]

0.92 [0.02, 51.21]

0.97 [0.02, 52.33]

SOR+IFN

.

.

.

.

0.85 [0.02, 45.10]

.

.

.

.

.

0.33 [0.20, 0.55]

0.45 [0.26, 0.78]

0.55 [0.33, 0.91]

0.57 [0.35, 0.94]

0.73 [0.45, 1.19]

0.75 [0.45, 1.23]

0.84 [0.55, 1.28]

0.88 [0.54, 1.45]

0.91 [0.50, 1.64]

0.92 [0.50, 1.71]

0.94 [0.48, 1.84]

0.98 [0.57, 1.71]

1.02 [0.02, 55.79]

ATE

.

.

.

.

.

.

.

.

.

0.31 [0.17, 0.55]

0.42 [0.23, 0.77]

0.51 [0.29, 0.91]

0.53 [0.30, 0.93]

0.69 [0.40, 1.18]

0.70 [0.40, 1.22]

0.78 [0.48, 1.29]

0.82 [0.47, 1.44]

0.85 [0.46, 1.57]

0.86 [0.45, 1.64]

0.88 [0.43, 1.80]

0.92 [0.65, 1.29]

0.95 [0.02, 52.25]

0.93 [0.49, 1.79]

EVE+BEV

.

.

.

.

.

.

.

.

0.30 [0.18, 0.52]

0.42 [0.23, 0.74]

0.51 [0.29, 0.87]

0.53 [0.31, 0.89]

0.68 [0.41, 1.13]

0.69 [0.41, 1.17]

0.78 [0.49, 1.22]

0.82 [0.48, 1.37]

0.84 [0.47, 1.51]

0.85 [0.46, 1.57]

0.87 [0.44, 1.73]

0.91 [0.69, 1.20]

0.94 [0.02, 51.51]

0.92 [0.50, 1.72]

0.99 [0.64, 1.54]

TEM+BEV

.

.

.

.

.

.

.

0.28 [0.19, 0.41]

0.38 [0.25, 0.59]

0.46 [0.31, 0.68]

0.48 [0.34, 0.70]

0.62 [0.44, 0.88]

0.63 [0.44, 0.92]

0.71 [0.55, 0.92]

0.75 [0.52, 1.08]

0.77 [0.47, 1.25]

0.78 [0.47, 1.32]

0.80 [0.45, 1.42]

0.83 [0.54, 1.29]

0.86 [0.02, 46.67]

0.85 [0.52, 1.39]

0.91 [0.52, 1.59]

0.92 [0.55, 1.54]

EVE

.

.

.

.

.

.

0.27 [0.19, 0.40]

0.37 [0.24, 0.58]

0.45 [0.31, 0.67]

0.48 [0.33, 0.68]

0.61 [0.44, 0.85]

0.62 [0.43, 0.89]

0.70 [0.55, 0.89]

0.73 [0.52, 1.05]

0.76 [0.54, 1.06]

0.77 [0.53, 1.12]

0.78 [0.44, 1.39]

0.82 [0.56, 1.21]

0.85 [0.02, 45.10]

0.83 [0.51, 1.36]

0.89 [0.53, 1.50]

0.90 [0.56, 1.45]

0.98 [0.69, 1.40]

SOR

.

.

1.14 [0.75, 1.74]

.

.

0.26 [0.16, 0.41]

0.35 [0.21, 0.59]

0.43 [0.27, 0.69]

0.45 [0.28, 0.71]

0.58 [0.37, 0.89]

0.59 [0.37, 0.92]

0.66 [0.46, 0.95]

0.69 [0.44, 1.09]

0.71 [0.42, 1.20]

0.73 [0.42, 1.26]

0.74 [0.39, 1.39]

0.77 [0.53, 1.13]

0.80 [0.01, 43.36]

0.78 [0.45, 1.38]

0.84 [0.50, 1.41]

0.85 [0.53, 1.36]

0.92 [0.59, 1.45]

0.94 [0.63, 1.41]

NAP+IFN

.

0.92 [0.70, 1.22]

.

.

0.22 [0.08, 0.60]

0.30 [0.11, 0.84]

0.37 [0.14, 1.00]

0.39 [0.14, 1.04]

0.50 [0.19, 1.32]

0.51 [0.19, 1.36]

0.57 [0.22, 1.47]

0.60 [0.22, 1.60]

0.61 [0.22, 1.73]

0.63 [0.22, 1.79]

0.64 [0.22, 1.88]

0.66 [0.24, 1.83]

0.69 [0.01, 41.24]

0.68 [0.24, 1.91]

0.72 [0.25, 2.11]

0.73 [0.26, 2.09]

0.80 [0.30, 2.13]

0.81 [0.30, 2.16]

0.86 [0.31, 2.39]

TEM

.

.

.

0.24 [0.16, 0.35]

0.32 [0.21, 0.50]

0.39 [0.27, 0.58]

0.41 [0.29, 0.59]

0.53 [0.38, 0.74]

0.54 [0.38, 0.77]

0.61 [0.48, 0.77]

0.64 [0.45, 0.91]

0.66 [0.42, 1.02]

0.67 [0.42, 1.07]

0.68 [0.38, 1.20]

0.71 [0.55, 0.92]

0.74 [0.01, 39.50]

0.72 [0.44, 1.18]

0.77 [0.50, 1.19]

0.78 [0.53, 1.14]

0.85 [0.60, 1.21]

0.87 [0.65, 1.15]

0.92 [0.70, 1.22]

1.07 [0.40, 2.84]

IFN

.

.

0.21 [0.12, 0.36]

0.29 [0.16, 0.51]

0.35 [0.20, 0.60]

0.37 [0.22, 0.62]

0.47 [0.28, 0.78]

0.48 [0.28, 0.81]

0.54 [0.34, 0.85]

0.57 [0.34, 0.95]

0.58 [0.32, 1.04]

0.59 [0.32, 1.09]

0.60 [0.30, 1.20]

0.63 [0.48, 0.83]

0.65 [0.01, 35.70]

0.64 [0.35, 1.19]

0.69 [0.44, 1.07]

0.69 [0.47, 1.03]

0.76 [0.45, 1.27]

0.77 [0.48, 1.24]

0.82 [0.51, 1.31]

0.95 [0.33, 2.71]

0.89 [0.61, 1.30]

IFN+PLA

.

0.15 [0.08, 0.27]

0.20 [0.11, 0.38]

0.25 [0.14, 0.45]

0.26 [0.14, 0.46]

0.33 [0.19, 0.59]

0.34 [0.19, 0.61]

0.38 [0.23, 0.64]

0.40 [0.25, 0.63]

0.41 [0.21, 0.80]

0.42 [0.21, 0.83]

0.43 [0.20, 0.89]

0.45 [0.24, 0.84]

0.46 [0.01, 25.58]

0.45 [0.23, 0.89]

0.49 [0.24, 1.00]

0.49 [0.25, 0.98]

0.53 [0.30, 0.95]

0.54 [0.31, 0.97]

0.58 [0.31, 1.09]

0.67 [0.23, 1.98]

0.63 [0.35, 1.11]

0.71 [0.36, 1.41]

PLA